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Contraindicated (1)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with strong CYP3A4 inducers; these drugs decrease exposure to vandetanib by up to 40%.Pentobarbital also will work by inhibiting glutamate, and that is answerable for nerve depol